Sustained Low Disease Activity in Lupus Linked to Reduced Risk for Damage and Flares

A threshold of sustained lupus low disease activity state or remission for 3 months significantly reduces the risk for damage accrual and flares in patients with systemic lupus erythematosus , with longer durations offering even greater protection. This large, prospective, multicenter study aimed to quantify the impact of sustained LLDAS on irreversible damage and flares.

It included 3449 patients with SLE from 25 centers across 12 countries, analyzing a total of 37,662 visits. Sustained LLDAS or remission was defined as at least two consecutive visits over > 3 months in the respective state.During a median follow-up of 2.8 years, 80.2% of patients achieved LLDAS at least once, with 72.7% experiencing at least one episode of sustained LLDAS."These findings support the use of these treat-to-target endpoints in clinical practice and provide a practical target to aim for in SLE treatment," the authors wrote.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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