Novel software that combines gene activity and tissue location to decode disease mechanisms

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A new computational machine learning method developed by computational biologists can help researchers discover spatial patterns of gene expression in diseased tissue.

Novel software that combines gene activity and tissue location to decode disease mechanisms." ScienceDaily. ScienceDaily, 3 June 2024. <www.sciencedaily.comUniversity of Colorado Anschutz Medical Campus. . Novel software that combines gene activity and tissue location to decode disease mechanisms.University of Colorado Anschutz Medical Campus."Novel software that combines gene activity and tissue location to decode disease mechanisms." ScienceDaily. www.sciencedaily.

R esearchers created a machine learning algorithm using computational topology that profiles shapes and spatial patterns in embryos to study how these cells organize themselves into tissue-like ... When genes are activated and expressed, they show patterns in cells that are similar in type and function across tissues and organs. Discovering these patterns improves our understanding of cells -- ...

A new computational approach successfully combines data from parallel gene-expression profiling methods to create spatial maps of a given tissue at single-cell resolution. The resulting maps can ... Scientists have devised a new computational method that reveals genetic patterns in the massive jumble of individual cells in the body. The discovery will be useful in discerning patterns of gene ...

 

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