Rheumatoid Arthritis Disease Activity Impacts Severity of Associated Interstitial Lung Disease

disease activity significantly affects the severity of interstitial lung disease , both radiologically and physiologically, in patients with RA and comorbid ILD.Impaired pulmonary function negatively affects the survival of patients with RA-ILD, making it necessary to evaluate the effect of RA disease activity on the severity of ILD.

Researchers assessed the associations between RA disease activity and ILD severity in 124 patients with RA who visited a rheumatology center between December 2020 and March 2023. ILD severity was determined using high-resolution computed tomography , with scores ranging from 0% to 100% , and pulmonary function tests such as forced vital capacity and predicted FVC%.

RA disease activity was assessed using the Disease Activity Score in 28 joints calculated with erythrocyte sedimentation rate and the Clinical Disease Activity Index .HRCT revealed that 17 patients had ILD, with ILD severity being mild , moderate , or severe in 7.2%, 2.4%, and 4.0% patients, respectively.IN PRACTICE:This single-center study included a small number of patients with ILD. Not all patients without ILD underwent pulmonary function tests.

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