Breakthrough research makes cancer-fighting viral agent more effective

Researchers from Aarhus University have made a significant breakthrough by discovering that the drug 4-OI can enhance the effectiveness of a cancer-fighting viral agent. This may lead to treatment of cancers that are otherwise resistant to therapies.

"We found that if we administer a specific viral agent called Vesicular Stomatitis Virus along with a metabolite-drug called 4-Octyl-Itaconate , we are able to treat cancers that are considered resistant to viral infections." "It is the combination of the specific virus and the drug that brings about a completely unique proviral effect, which potentially can have a significant impact on patients affected by cancer that we are currently unable to treat," explains David Olagnier.

For the research team, the next step is a more extensive pre-clinical testing of the combinational use of VSVD51 and 4-OI.

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