Cancer Treatment Breakthrough: Researchers Develop Less Toxic, More Effective Chemotherapy

A groundbreaking cancer treatment developed by NUS researchers utilizes engineered bacteria to deliver chemotherapy drugs directly to tumor sites, significantly enhancing treatment efficacy and reducing side effects.Traditional chemotherapy frequently presents substantial difficulties, such as harsh side effects, harm to healthy cells, and restricted effectiveness.

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore , have pioneered a groundbreaking cancer treatment method. This new technique offers a more precise, potent, and less harmful alternative to conventional chemotherapy. It not only enhances the efficacy of the treatment but also substantially lowers the dosage of drugs needed for cancer therapy.

Led by Associate Professor Matthew Chang, researchers at the NUS Synthetic Biology for Clinical and Technological Innovation and the Synthetic Biology Translational Programme at NUS Medicine identified a new method of drug delivery that offers hope for the development of a new clinical treatment for cancer patients. The findings, published in, showcase a novel method for delivering chemotherapy drugs directly to tumor sites by utilizing the natural interactions between bacteria and cancer cells.

“Cancer treatment often takes a tremendously heavy toll on patients. Our research represents a significant step toward developing a more targeted and less toxic approach to fighting cancer. We hope this can pave the way for therapies that are both mild and effective,” added A/Prof Chang, Dean’s Chair in Medicine and Director of SynCTI and NUS Medicine Syn Bio TRP.

Reference: “Prodrug-conjugated tumor-seeking commensals for targeted cancer therapy” by Haosheng Shen, Changyu Zhang, Shengjie Li, Yuanmei Liang, Li Ting Lee, Nikhil Aggarwal, Kwok Soon Wun, Jing Liu, Saravanan Prabhu Nadarajan, Cheng Weng, Hua Ling, Joshua K. Tay, De Yun Wang, Shao Q. Yao, In Young Hwang, Yung Seng Lee and Matthew Wook Chang, 21 May 2024,SciTechDaily: Home of the best science and technology news since 1998. Keep up with the latest scitech news via email or social media.

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