Apr 12 2024BMJ A single low dose injection of esketamine given immediately after childbirth reduces major depressive episodes in individuals with depressive symptoms during pregnancy , finds a clinical trial published by The BMJ today.
Esketamine is made from a drug called ketamine. It's used as an anesthetic and to treat depression, yet the effect for mothers with perinatal depression is unclear. None of the participants had severe pregnancy complications, or any condition that meant they couldn't be given esketamine. As expected, mothers given esketamine had lower Edinburgh depression scores at 7 and 42 days, and a lower Hamilton depression score at 42 days.
The researchers acknowledge that excluding mothers with pre-pregnancy mood disorders may have affected the validity of their results, and the short follow-up period may have led to under-reporting of neuropsychiatric symptoms and other adverse events.
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