Mar 21 2024European Organisation for Research and Treatment of Cancer The vast majority of young patients given a low-dose boost of radiotherapy to the site where their breast cancer was removed in addition to whole breast radiotherapy, remained free of local recurrence after ten years, according to results of the 'Young boost trial' presented at the 14th European Breast Cancer Conference.
The research was presented by Dr Sophie Bosma, a radiation oncologist at The Netherlands Cancer Institute in Amsterdam. She said: "Young breast cancer patients generally have a worse prognosis than older patients. However, because breast cancer is more common in older women, younger women are under-represented in most breast cancer studies.
The trial included 2421 patients who were all aged 50 or younger, with an average age of around 45, and being treated at one of 32 centers in The Netherlands, France, or Germany. Following surgery to remove their tumors and whole breast radiotherapy, the patients were randomly assigned to be treated with either the low-dose or high-dose radiotherapy boost. The majority of patients also received chemotherapy.
However, 48% of patients who received the high dose experienced severe or moderate fibrosis in the breast, compared with 27% of patients who received the low dose. Overall, the researchers conclude that the 'benefit does not justify the increased impact on cosmetic outcomes'.
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