Vitamin D Not Tied to Clinical, Histologic Features of EoE

in EoE incidence and the association of low vitamin D levels with increased risk for allergic sensitization prompted the researchers to assess whether vitamin D levels were lower in patients newly diagnosed with EoE than in people without the disease, and whether the levels affected EoE clinical features.

The 40 control participants had a mean age at diagnosis of 50.9 years; 33% were men, 75% were White, 38% were atopic, and 30% were taking vitamin D supplements at diagnosis. After controlling for age, sex, and race, adjusted 25D3 levels were 10.8 ng/mL lower in patients with EoE. However, 25D3 deficiency was similar in patients with EoE and the control group .

"Though only a subset of cases had lamina propria tissue for evaluation, vitamin D is known to have a crucial role in developing pulmonary fibrosis due to various molecular mechanisms," the authors wrote. "Therefore, development of EoE fibrosis in the setting of vitamin D deficiency warrants further investigation."

Vitamin D deficiency is associated with a more severe disease state in other chronic type 2 inflammatory disorders, such as, and atopic rhinitis, and supplementation improves the overall disease, Gupta and Bredenoord wrote. Because of these conditions' shared pathway for inflammation and epithelial barrier disruption, it could be assumed that a larger number of atopic diseases would be linked with greater likelihood of low vitamin D levels, they added.

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