and physicians," said Tetsuya Mitsudomi, MD, Division of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama, Japan
Patients were randomized to receive either neoadjuvant durvalumab 1,500 mg or placebo intravenously alongside platinum-based CT prior to surgery. Following surgery, patients received durvalumab 1,500 mg or placebo IV, respectively. The primary endpoints of the trial were pathological complete response and event-free survival.
Lobectomy, sleeve resection, or bilobectomy were allowed as planned surgery ; the protocol was amended with enrollment ongoing to exclude patients with tumors classified as T4 for any reason other than size or whose planned surgery was pneumonectomy .
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