Combination treatment shows benefit for patients with extensive-stage small-cell lung cancer

In this multicenter, placebo-controlled, randomized phase III trial, patients with first-line extensive-stage small-cell lung cancer were randomly assigned to receive either four cycles of benmelstobart, anlotinib, or placebo in combination with etoposide/carboplatin chemotherapy. This treatment was followed by maintenance therapy of benmelstobart + anlotinib, anlotinib alone, or placebo untilor toxicity intolerance.

Dr. Cheng and colleagues enrolled a total of 738 patients from 72 participating centers in China, with 246 patients assigned to the benmelstobart, anlotinib and chemotherapy arm and 247 patients assigned to the placebo and chemotherapy arm. As of the cutoff date , the median follow-up was 14.0 months.

The combination of benmelstobart, anlotinib, and chemotherapy demonstrated significant benefits compared toand chemotherapy in terms of median PFS , median OS , objective response rate , and duration of response . The safety profile of the benmelstobart, anlotinib, and chemotherapy regimen was manageable and tolerable, with grade ≥3 treatment-related adverse events reported in 93.1% of patients in the treatment arm. The most common grade ≥3 treatment-related adverse events included decreased neutrophil count, decreased platelet count, and decreased white blood cell count. Immune-related adverse events were also reported in a subset of patients.

"These results from the phase III trial are extremely encouraging, as the combination of benmelstobart, anlotinib, and chemotherapy achieved historically long overall survival and

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