Bacteria in the gut may be a cause of Parkinson’s disease, study finds

strains isolated from healthy individuals did not cause the same level of protein accumulation. While the clumps formed by these bacteria strains in Parkinson's disease patients were also found to be larger.

“Our findings make it possible to screen for the carriers of these harmful Desulfovibrio bacteria. Consequently, they can be targeted by measures to remove these strains from the gut, potentially alleviating and slowing the symptoms of patients with Parkinson’s disease. Once the Desulfovibrio bacteria are eliminated from the gut, α-synuclein aggregates are no longer formed in intestinal cells, from which they travel towards the brain via the vagus nerve like prion proteins,” concludes Saris.

The study is conducted by researchers from the University of Helsinki and the University of Eastern Finland. The study has been published in the journalIntroduction: The aggregation of the neuronal protein alpha-synuclein is a key feature in the pathology of Parkinson’s disease . Alpha-syn aggregation has been suggested to be induced in the gut cells by pathogenic gut microbes such as Desulfovibrio bacteria, which has been shown to be associated with PD.

Methods: Fecal samples of ten PD patients and their healthy spouses were collected for molecular detection of Desulfovibrio species, followed by bacterial isolation. Isolated Desulfovibrio strains were used as diets to feed Caenorhabditis elegans nematodes which overexpress human alpha-syn fused with yellow fluorescence protein. Curli-producing Escherichia coli MC4100, which has been shown to facilitate alpha-syn aggregation in animal models, was used as a control bacterial strain, and E.

Health Health Latest News, Health Health Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Some Pilot COVID-19 At Home Tests recalled by FDA over bacteria risk | CNNThe US Food and Drug Administration issued a warning on Friday to consumers and health providers to discontinue using and discard recalled Pilot COVID-19 At-Home Tests made by SD Biosensor, Inc. over 'significant concerns' of bacterial contamination.
Source: CNN - 🏆 4. / 95 Read more »

How Scientists Are Using Bacteria To Make Salmon HealthierBacteria-free fish fry put scientists on the track to make fish more disease resistant. Researchers, including those from NTNU, are breeding bacteria-free fish fry. This is more important than you think. “We’re managing to keep the fry bacteria-free for up to 12 weeks after the eggs hatch,” says
Source: SciTechDaily1 - 🏆 84. / 68 Read more »

Updates and Expert Perspectives on Dopamine Receptor Agonists in Parkinson Disease📝 Why do we need more selective treatments for Parkinson disease? PD MedEd ➡️
Source: Medscape - 🏆 386. / 55 Read more »

Parkinson's May Be Caused by a Common Aquatic BacteriumA common genus of microbe found in wet, boggy environments could play a key role in the development of Parkinson's disease, by excreting compounds that trigger proteins inside brain cells to form toxic clumps.
Source: ScienceAlert - 🏆 63. / 68 Read more »