Parkinson's May Be Caused by a Common Aquatic Bacterium

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A common genus of microbe found in wet, boggy environments could play a key role in the development of Parkinson's disease, by excreting compounds that trigger proteins inside brain cells to form toxic clumps.

With Saris's 2021 study, there was finally evidence of a single prime suspect researchers could focus on.

Of course, there's a world of difference between worms and humans. While the same experiment could never be replicated in a sample of healthy people, studies will continue to look closely at waysin our own guts might spark the formation of α-synuclein aggregates that could migrate through the body. In time, we may even be able to manage the progress of Parkinson's disease using therapies that target the digestive system and its surrounding nerves, instead of the brain.bacteria are eliminated from the gut, α-synuclein aggregates are no longer formed in intestinal cells, from which they travel towards the brain via the vagus nerve like prion proteins,"

 

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