Long COVID Treatment Research Is Stuck in a Frustrating Catch-22

, anticoagulants, antivirals, beta blockers, statins, antihistamines to calm overactive mast cells, and probiotics to improve gut health. Several of these have reportedly helped people with ME/CFS, and some have shown promise in small studies.“It’s really about not reinventing the wheel,” said Hannah Davis, a machine learning researcher who co-founded theafter developing long COVID in early 2020.

Therapies proposed by patients and researchers include everything from the abortion pill mifepristone and Viagra to repurposed HIV and hepatitis C drugs to psilocybin and natural blood thinners made from worms. But navigating these waters: For every patient who reports improvement, others say they saw no change or got worse. Long COVID symptoms can wax and wane, and without randomized controlled trials, it’s hard to know who would have improved without any intervention at all, by simply waiting.

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