MD Anderson Cancer Center has made a major impact in the area of pancreatic cancer research. Their recent study highlights several key aspects of the biology of pancreatic cancer that could serve as targets for therapeutic intervention. These aspects include genomic changes, metabolic processes, the tumor’s microenvironment, the use of immunotherapy, and the implementation of innovative clinical trial designs.
The authors emphasize the importance of approaching the disease from multiple angles, encompassing as many of the hallmarks as possible for the highest chance of success. The authors also discuss how advances in single-cell analysis and high-dimensional spatial profiling techniques have revealed the diversity of cell populations dynamically interacting within pancreatic tumors and discuss how to begin disrupting these networks to improve response to treatment.
“The previous 10 years have already seen the 5-year survival rate of PDAC double after remaining stagnant for decades prior. We are confident that the collective efforts of the scientific community will continue this trend to transform PDAC from a recalcitrant disease to a manageable disease,” said Halbrook.
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