]. All these studies, including the current study, emphasise that vitamin D levels can normalise with oral supplementation and is safe. However, the effect on lupus activity and IFN signature are still not established. This could be because of the variable duration of several studies and the use of background immunosuppressive agents whose effect might be so high that added impact of vitamin D may not be evident.
The strength of our study is the large sample size with details about the usual confounders for vitamin D levels. Moreover, the samples were collected at the beginning of recruitment into the cohort, thus decreasing the effect of background immunosuppressive agents. The sample collection in both the centres was conducted round the year, which negates the effect of seasonal variation in vitamin D levels.
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Clinical outcomes of pediatric osteomyelitis - BMC PediatricsBackground Osteomyelitis in children may produce severe sequelae. However, the frequency and distribution of such complications by type of osteomyelitis (chronic or acute) is not well described. Methods We searched the HealthFacts® database (containing medical information on 68 million individual patients in the United States) with 238 International Classification of Diseases (ICD) version 10 codes for acute osteomyelitis and chronic osteomyelitis appearing in 2015. Outcomes were recorded for each subject, including development of limb length discrepancies, pathologic fractures, mortality, and need for multiple surgeries or prolonged orthopedic care (one to two years following diagnosis). Gender, age and season of diagnosis were also assessed. Chi-square tests were used to compare differences between categorical variables, and t-tests between continuous variables. Results Eight hundred sixty-nine subjects were included (57.4% male). Children with chronic osteomyelitis were older than those with acute osteomyelitis (median 9.5 years vs 12.0, respectively, p = .0004). Diagnoses were more common in winter (p = .0003). Four subjects died while hospitalized during the study period (two with acute osteomyelitis, two with chronic osteomyelitis). Limb length discrepancies were rare and similarly distributed between infection types (≤ 1.3% of subjects, p = .83). Subjects with chronic osteomyeltis were more likely to require long-term orthopedic follow-up (14.0% vs. 4.8% for acute osteomyelitis, p | .0001), suffer from pathologic fractures (1.5% vs | 1.0%, p = .003) and to require multiple surgeries (46.0% vs. 29.3%, p = .04). Conclusions Though infrequent, serious outcomes from osteomyelitis are more common with chronic osteomyelitis than acute osteomyelitis.
Source: BioMedCentral - 🏆 22. / 71 Read more »
Press Association corrects error in reporting on research for prostate cancer test - Full FactResearch on a new test for prostate cancer was reported on by several major news outlets but wrongly stated: - the accuracy of a test trialled - the number of trialists with cancer - the number of trialists who tested positive Following our investigation, corrections were made by the study authors, the Press Association and the Daily Mail. People just read the headlines, not the small print
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Sleep characteristics of middle-aged adults with non-alcoholic fatty liver disease: findings from the Shahrekord PERSIAN cohort study - BMC Public HealthBackground Several studies have reported short sleep duration in people with non-alcoholic fatty liver disease (NAFLD) but other sleep characteristics have been less studied. We aimed to assess the cross-sectional association of NAFLD with sleep duration and quality in an Iranian population sample. Methods We used data from 9,151 participants in the Shahrekord Prospective Epidemiological Research Studies in Iran (PERSIAN) Cohort Study, including 1,320 that were diagnosed with NAFLD. Log-binomial regression models sequentially adjusted for sociodemographic, lifestyle, clinical and biological variables were used to estimate relative risks (RR) and 95% confidence intervals (95% CI) for the association between NAFLD and sleep characteristics. Results Participants with NAFLD had shorter sleep duration, later wake-up time and bedtime, worse sleep efficiency, and more frequent daytime napping and use of sleeping pills, in age- and sex-adjusted models. After controlling for sociodemographic, lifestyle, clinical, and biological variables the associations remained strong for sleep efficiency (per 10%, RR = 0.92, 95%CI: 0.88–0.96) and use of sleeping pills (RR = 1.48, 95%CI: 1.17–1.88). The association between NAFLD and sleep efficiency was stronger in participants aged | 60 years (RR = 0.81, 0.70–0.93) and 40–60 years (RR = 0.87, 0.82–0.94), compared with those aged | 40 years (P-heterogeneity | 0.001). More frequent daytime napping in participants with NAFLD, compared with non-NAFLD, was observed in males but not females (P-heterogeneity = 0.007), and in those with body mass index (BMI) | 30 but not in obese participants (P-heterogeneity | 0.001). Conclusions Diagnosis of NAFLD is associated with several poor sleep characteristics in middle-aged Iranians. Although longitudinal studies would help to clarify the direction of causality, our study shows that poor sleep is an important aspect of NAFLD.
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