3
. Most associations appeared consistent across subgroups, in particular for restless legs syndrome, use of sleeping pills, and waking-up time. For sleep efficiency, the associations varied by age, being substantially stronger in older participants , and by BMI, being stronger in obese participants . Male participants who reported daytime napping were 27% more likely to have NAFLD but no association was observed in females , P-heterogeneity = 0.007.
Table 3 Interaction between sleeping characteristics and the factors in association with NAFLD using likelihood ratio testOur study examined the association between NAFLD and several sleep-related variables, including sleep duration and efficiency, wake-up and bed time, and variables indicative of poor sleep such as falling sleep unintentionally, having restless legs syndrome, and using sleeping pills, in a large cohort of ethnically-diverse middle-aged Iranian men and women.
The strengths of our study were i) its large sample size, including 1,320 NAFLD cases drawn from a population-based cohort, ii) the clinical diagnosis of NAFLD made by ultrasonography; and iii) the adjustment for an extensive collection of sociodemographic, lifestyle, and clinical/biochemical variables. Our study also has several limitations.
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Study on the correlation between B vitamins and breast cancer - Cancer Cell InternationalBackground Relevant studies suggest that serum vitamin level is related to the risk of breast cancer, and dietary pattern and drug supplementation can significantly affect the level of vitamin in the body. Therefore, intervention of vitamin level in the body is expected to be a potential strategy to reduce the risk of breast cancer. However, the current epidemiological findings of serum vitamin levels and breast cancer risk are inconsistent, and the relationship between serum vitamin and breast cancer is still controversial. In this study, we compared the serum vitamin expression levels of healthy people, benign breast patients, and breast cancer patients, and evaluated the relationship between B vitamin levels and breast cancer risk. Methods The study used liquid chromatography-tandem mass spectrometry to determine the serum vitamin levels of 520 people who attended Yunnan Cancer Hospital from September 2020 to December 2020. After screening by exclusion criteria, 38 patients with benign breast diseases, 87 patients with breast cancer and 91 healthy controls were finally included. The kruskal–wallis H test was used to compare the differences in serum vitamin levels of subjects. Χ2 test was used to evaluate the relationship between B vitamin level and age,BMI,TNM staging,Ki-67,Her-2,surgery and chemotherapy, and other baseline characteristics and through binary logistic regression analysis, calculating odds ratio and 95% confidence interval (CI) to evaluate the relationship between B vitamins and breast cancer risk. Conclusion The levels of VitB1 and VitB5 in the serum of breast cancer patients and patients with benign breast diseases were higher than those in the healthy control group, while the expression levels of VitB3 in breast cancer patients were lower than those in the healthy control group and the breast benign disease groups. The level of VitB1 was positively correlated with breast cancer risk. The VitB3 level was negatively correlated with breast cancer r
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