By Pooja Toshniwal PahariaJan 20 2023Reviewed by Aimee Molineux In a recent study published in Science Immunology, researchers evaluated immunoglobulin G responses to coronavirus disease 2019 messenger ribonucleic acid vaccinations.
The study analyzed humoral responses among a group of healthcare workers to triple Comirnaty mRNA vaccinations. The second cohort comprised 38 three-dose Comrinaty vaccinees. individuals. The prime doses were administered 21 days to 28 days apart, followed by the third dose after 7.0 months of the prime vaccination.
Further, flow cytometry analysis was performed to characterize anti-S memory B lymphocytes by IgG subclasses among PBMC samples, obtained from 11 individuals post-second dose and third dose administration. Additionally, single-cell RNA sequencing analysis was performed for anti-S B lymphocytes obtained from four donor individuals 210.0 days post-second dose and 10.0 days post-third dose of Comirnaty vaccines.
Results After 5.0 months to 7.0 months of the second mRNA vaccination, anti-SARS-CoV-2 IgG responses primarily comprised the non-inflammatory immunoglobulin G4 subclass and were enhanced by the booster dose or breakthrough infection. Among all anti-S IgG titers, IgG4 titers elevated from a mere 0.04 percent shortly post-second dose to 19 percent late post-third dose. In addition, IgG4 responses were not induced post-heterologous or homologous doses of the COVID-19 adenovirus-vectored vaccines.
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