Neural stem cell transplantation in patients with progressive multiple sclerosis: an open-label, phase 1 study - Nature Medicine

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Results from a Phase 1 clinical trial reveal that intrathecal transplantation of fetal neural precursor cells in patients with progressive MultipleSclerosis is feasible, safe and tolerable. MS EndMS StemCellTransplantation NMEDClinical

The EDSS is based on a standard neurological examination, incorporating seven functional systems rated and stored as functional system scores . Each FSS is an ordinal clinical rating scale ranging from 0 to 5 or 6. These ratings are then used in combination with ambulation capacity to determine the EDSS score that ranges from 0 to 10 . Sustained disability progression is defined as an increase of >0.5 EDSS points in the last 12 months.

Global pRNFL thickness was automatically measured through the pre-installed software provided by the manufacturer. pRNFL thinning and p100 latency increase may also occur as a result of MS-associated optic neuritis . Patients were categorized into those with prior history of MS-ON and those without MS-ON and assessed accordingly. For patients with a history of MS-ON in one eye, the eye without prior MS-ON was studied.

 

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Sounds interesting. Any info on the future phases of the trial?

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