"Sleep deprivation undermines memory presses, but every student knows that an answer that eluded them during the exam might pop up hours afterward. In that case, the information was, in fact, stored in the brain, but just difficult to retrieve."Havekes and his team adopted an optogenetic strategy in which they genetically engineered neurons that are stimulated during a learning experience to manufacture a light-sensitive protein selectively.
"In our sleep deprivation studies, we applied this approach to neurons in the hippocampus, the area in the brain where spatial information and factual knowledge are stored," said Havekes.The medication roflumilast, which is taken by people with asthma or COPD, also targets the biochemical pathway triggered during the reactivation.roflumilast just before the second test, they remembered, exactly as happened with the direct stimulation of the neurons," Havekes said.
These discoveries bring up opportunities to explore if roflumilast can be used to give individuals access to lost memories, as it is already clinically licensed for use in humans and is known to penetrate the brain.more information than we previously thought and that these "hidden" memories can be accessed once more, at least in mice, throws up a world of intriguing possibilities.
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Source: SciTechDaily1 - 🏆 84. / 68 Read more »
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