Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Meta-analyses from prospective studies, literature search, study selection, data extraction, displaying of findings.Flow diagram of literature search and study selection for the meta-analysis.Characteristics of prospective studies and previous individual participant data meta-analysis of body mass index and prostate cancer death.
Mean difference in MRI- and DXA-derived body fat compartments per 1 SD higher levels of BMI, body fat percentage, waist circumference, and waist to hip ratio in men from UK Biobank.Geometric means of selected MRI measurements by tenths of anthropometric measurements at the imaging visit in up to 11,501 men from UK Biobank.Geometric means of selected DXA measurements by tenths of anthropometric measurements at the imaging visit in up to 18,827 men from UK Biobank.
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Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders - BMC MedicineBackground Prenatal alcohol exposure (PAE) affects embryonic development, causing a variable fetal alcohol spectrum disorder (FASD) phenotype with neuronal disorders and birth defects. We hypothesize that early alcohol-induced epigenetic changes disrupt the accurate developmental programming of embryo and consequently cause the complex phenotype of developmental disorders. To explore the etiology of FASD, we collected unique biological samples of 80 severely alcohol-exposed and 100 control newborns at birth. Methods We performed genome-wide DNA methylation (DNAm) and gene expression analyses of placentas by using microarrays (EPIC, Illumina) and mRNA sequencing, respectively. To test the manifestation of observed PAE-associated DNAm changes in embryonic tissues as well as potential biomarkers for PAE, we examined if the changes can be detected also in white blood cells or buccal epithelial cells of the same newborns by EpiTYPER. To explore the early effects of alcohol on extraembryonic placental tissue, we selected 27 newborns whose mothers had consumed alcohol up to gestational week 7 at maximum to the separate analyses. Furthermore, to explore the effects of early alcohol exposure on embryonic cells, human embryonic stem cells (hESCs) as well as hESCs during differentiation into endodermal, mesodermal, and ectodermal cells were exposed to alcohol in vitro. Results DPPA4, FOXP2, and TACR3 with significantly decreased DNAm were discovered—particularly the regulatory region of DPPA4 in the early alcohol-exposed placentas. When hESCs were exposed to alcohol in vitro, significantly altered regulation of DPPA2, a closely linked heterodimer of DPPA4, was observed. While the regulatory region of DPPA4 was unmethylated in both control and alcohol-exposed hESCs, alcohol-induced decreased DNAm similar to placenta was seen in in vitro differentiated mesodermal and ectodermal cells. Furthermore, common genes with alcohol-associated DNAm changes in placenta and hESCs were linke
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Pharmacies are running out of cold and flu medicine as winter bugs continue to spread🔴 Throat lozenges, cough mixtures and some pain killers are in short supply, according to the Association of Independent Multiple Pharmacies
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NHS faces three months of turmoil as hospitals warn patients to avoid A&E unless dyingThe heads of the British Medical Association, Society for Acute Medicine and Royal College of Emergency Medicine said staff are desperately trying to keep up with intense demand at hospitals nationwide PMGallagher1 mollyblackall It's already faced 12 years of Tory turmoil PMGallagher1 mollyblackall only three? PMGallagher1 mollyblackall Hi Molly & Paul, As you cover health,nhs strikes, waiting lists and travel would you be interested on reporting on a health care elsewhere specifically 🇹🇷 Turkey. I am organising a press trip to Istanbul end of Feb for Acibadem. Can we chat about this? NICOLAOGGADOON.CO.UK
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Newscast - NHS Under Pressure - BBC Sounds🏥 Doctors describe “gridlock” in hospitals 😷 New mask advice 🚊 Who could go on strike next? Hear more on the latest BBCNewscast Totally 🤷♂️
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Parminder Nagra explores working motherhood in new ITV dramaWe spoke to actor Parminder Nagra about her drama Maternal which follows three doctors returning to frontline medicine after maternity leave.
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Flu crisis triggers shortage of Night Nurse and Lemsip remediesTHE flu crisis has triggered a shortage of popular remedies Night Nurse and Lemsip. The medicine cabinet essentials are in short supply across pharmacies and supermarkets. Lloyds Pharmacy has compl… 'Flu crisis.' No it hasn't...more lies!!!!
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