The Institute of Cancer Research says it has launched a"really exciting" five-year research strategy which hopes to"unravel and disrupt cancer's ecosystems".The survival of people with advanced cancer could double within a decade, say scientists involved in cutting-edge research.
ICR and Royal Marsden scientists believe they can make significant progress in areas such as destroyingcells, boosting the body's power to fight the disease, and stopping healthy cells cell being tricked into helping cancer survive. Researchers will also look further into the microscopic fragments of cancer that are shed into the bloodstream with the aim of catching the disease in its earliest stages.
surviving cancer isnt a cake walk, the daily pain sucks. the every 3 month check up sucks. getting cut and waiting on biopsies sucks.
The irony of this article published at a time when “simpler” cancers have gone undiagnosed, largely due to & other media’s actions which lead to the cancer crisis in our country. So , what percentage of the 500k excess deaths do you take responsibility for?
Interesting 🧐
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Frontiers | Identification of a naturally-occurring canine model for early detection and intervention research in high grade urothelial carcinomaBackground: Early detection and intervention research is expected to improve the outcomes for patients with invasive urinary bladder cancer, specifically muscle invasive urothelial carcinoma (InvUC). With limited patients in suitable high-risk study cohorts, identifying relevant animal models for this research is critical. Experimental animal modes, while essential in InvUC research, often fail to adequately represent human cancer, and fail to predict drug responses. The purpose of this study was to define a naturally-occurring canine model for early intervention research by studying dogs with high breed-associated risk for InvUC, e.g. Scottish Terriers (STs). Methods: STs (n=120) ≥ 6 years old with no outward evidence of urinary disease were screened at 6-month intervals for 3 years. Screening included physical exam with digital rectal exam, ultrasonography, and urinalysis with sediment exam. Cystoscopic biopsy was performed in dogs with positive screening tests. The pathological, clinical, and molecular characteristics of the “early” cancer detected by screening were determined. Transcriptomic signatures were compared between the early tumors and published findings in human InvUC, and to more advanced “later” canine tumors from STs who had the typical clinical presentation of hematuria and urinary dysfunction. An early intervention trial of an oral cyclooxygenase inhibitor, deracoxib, was conducted in dogs with cancer detected through screening. Results: Biopsy-confirmed bladder cancer was detected in 32 (27%) of 120 STs including InvUC (n=29, three starting as dysplasia), grade 1 noninvasive cancer (n=2), and carcinoma in situ (n=1). Transcriptomic signatures including druggable targets such as EGFR and the PI3K-AKT-mTOR pathway, were very similar between canine and human InvUC, especially within luminal and basal molecular subtypes. Marked transcriptomic differences were noted between the early and later canine tumors, particularly within luminal subtype tumors. LifeAtPurdue we dont accept that as a social credit /lucrative for insurance! If not thats be a good thing i guess
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Linda Nolan forced to deny being drunk after chemotherapy side effectsLinda Nolan has been force to deny being drunk in the middle of the day due to side effects of her cancer treatment.
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