B Vitamins May Be Inexpensive Treatment for Advanced Non-Alcoholic Fatty Liver Disease

Singapore scientists find hyperhomocysteinemia strongly correlates with the severity of non-alcoholic steatohepatitis.

A mechanism that leads to an advanced form of fatty liver disease has been uncovered by scientists at Duke-NUS Medical School in Singapore. It turns out that vitamin B12 and folic acid supplements could reverse this process. “While fat deposition in the liver is reversible in its early stages, its progression to NASH causes liver dysfunction, cirrhosis and increases the risk for liver cancer,” said Dr. Madhulika Tripathi, first author of the study, who is a senior research fellow with the Laboratory of Hormonal Regulation at Duke-NUS’ Cardiovascular & Metabolic Program.

Dr. Tripathi, study co-author Dr. Brijesh Singh and their colleagues in Singapore, India, China, and the US confirmed the association of homocysteine with NASH progression in preclinical models and humans. They also discovered that, as homocysteine levels increased in the liver, the amino acid attached to various liver proteins, changing their structure and impeding their functioning.

“Our findings are both exciting and important because they suggest that a relatively inexpensive therapy, vitamin B12, and folic acid, could be used to prevent and/or delay the progression of NASH,” said Dr. Singh. “Additionally, serum and hepatic homocysteine levels could serve as a biomarker for NASH severity.”

B vitamins accumulate in the body and can become toxic. The best cure for fatty liver disease is exercise and weight loss. Ditto diabetes. Insulin (like statins) is poison. Sleep, healthy diet, reduced stress & exercise are among the usual & the best remedies.

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