REUTERS: An experimental drug developed by Seattle Genetics Inc and Astellas Pharma Inc led to significant, rapid tumor shrinkage in patients with advanced bladder cancer who had been previously treated with immunotherapy and chemotherapy in a midstage trial, according to data presented on Monday.In the 125-patient study of the drug, enfortumab vedotin, the overall response rate was 44per cent, meaning tumors were at least 30per cent smaller for those patients.
The companies, which share development costs and eventual profits, believe the data to be strong enough to seek accelerated approval with U.S. regulators this year. While the trial was not designed to demonstrate a statistically significant benefit on overall survival, half the patients were still alive after 11.7 months. Typical median overall survival for metastatic bladder cancer is about 9 months.
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