Form of B12 Deficiency Affecting the Central Nervous System May Be New Autoimmune Disease

Researchers have identified a form of B12 deficiency caused by autoantibodies that specifically affects the central nervous system.

Using this method, he and colleagues discovered that this woman had autoantibodies that target CD320 — a receptor important in the cellular uptake of B12. While her blood tests were normal, B12 in the patient's cerebral spinal fluid was"nearly undetectable," Pluvinage said. Using an in vitro model of the blood-brain barrier , the researchers determined that anti-CD320 impaired the transport of B12 across the BBB by targeting receptors on the cell surface.

Researchers also screened for anti-CD320 seropositivity in 408 patients with non-neurologic SLE and 28 patients with neuropsychiatric SLE and found that the autoantibody was nearly four times as prevalent in patients with neurologic symptoms compared with in those with non-neurologic SLE .

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