Rapamycin may slow aging. Here's one way the drug will be tested

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Longevity researchers are taking a generic drug they think may help extend people's lives. Now a dentist is testing if rapamycin stops gum disease — a canary in the coal mine for age-related diseases.

A generic drug that's used to treat transplant patients has been shown to extend the life span of some animals.was diagnosed with a frozen shoulder. “It was really bad,” he recalls. He wasn’t sleeping well and couldn’t throw a ball due to the pain. His doctor recommended physical therapy, and told him that it mayhave started taking the drug in hopes of fending off age-related health problems.

There’s already some evidence from transplant patients that rapamycin may help improve oral health. And as part of the study, An and his collaborators will also measure changes in participants’ microbiomes and their biological clocks.who have gum disease. They will take the drug, at various doses, intermittently for 8 weeks. Then, An will be able to determine if the drug is safe and effective.

“If we can target that underlying biology, we predict that it might address a lot of these other underlying conditions,” An says.

 

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