Longevity researchers are taking a generic drug they think may help extend people's lives. Now a dentist is testing if rapamycin stops gum disease — a canary in the coal mine for age-related diseases.A generic drug that's used to treat transplant patients has been shown to extend the life span of some animals.was diagnosed with a frozen shoulder. “It was really bad,” he recalls. He wasn’t sleeping well and couldn’t throw a ball due to the pain.
There’s already some evidence from transplant patients that rapamycin may help improve oral health. And as part of the study, An and his collaborators will also measure changes in participants’ microbiomes and their biological clocks.who have gum disease. They will take the drug, at various doses, intermittently for 8 weeks. Then, An will be able to determine if the drug is safe and effective.
Dr. An thinks gum disease may be a kind of canary in the coalmine of age-related diseases. For instance, gum disease is linked to a. Scientists say it’s possible that bacteria in the mouth linked to periodontal disease causes inflammation, which may cause a “cascade” of damage to blood vessels, leading to problems in the heart or brain.
Rapamycin is a generic drug, so pharmaceutical companies have little incentive to fund new research. An and his collaborators have received ato conduct the trial, which could open the door to further studies to determine whether rapamycin can help prevent or slow down other age-related diseases., a physician who heads the Buck Institute for Research on Aging, says his group is fundraising for more research on rapamycin.
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