University of Pennsylvania School of MedicineJun 28 2024 A team of researchers led by Penn Medicine will investigate the link between traumatic brain injuries and Alzheimer's disease and related dementias over the next five years with a $10 million grant from the National Institute of Neurological Disorders and Stroke .
The team of 26 investigators across 12 sites aims to uncover the type and extent of neuropathological changes that emerge after TBI. They will evaluate the pathologies from a variety of types of TBI which could range from a single, severe injury, like from a car accident, to mild, repetitive injuries, which can occur while playing a contact sport. The team will also look at TBI, that results from military combat and intimate partner violence.
TRANSFORM-TBI is the second phase of research to study TReND. In 2019, Smith, Lee and Willie Stewart of the University of Glasgow, UK, established CONNECT-TBI-;a program spanning 12 institutions to establish diagnostic criteria for TReND. To date, CONNECT-TBI has gathered clinical datasets and tissue archives from over 1,000 cases across participating centers.
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