University of Texas Health Science Center at San AntonioJun 21 2024 Research led by in part by The University of Texas Health Science Center at San Antonio finds that the most common cerebral small-vessel disease feature seen in brain magnetic resonance imaging is a primary vascular factor associated with dementia risk.
Sargurupremraj is the first and co-corresponding author of the research, titled, "Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia," published May 22 in JAMA Network Open, a monthly open-access medical journal published by the American Medical Association. Still, while observational studies had shown evidence of an association between white matter hyperintensity burden and increased risk of stroke and dementia, causal evidence had been limited. White matter hyperintensities are lesions in the brain that show up as areas of increased brightness in T2-weighted magnetic resonance imaging.
The study also highlighted the importance of combining several complementary epidemiological approaches and data types, and of accounting for caveats of instrumental variable analyses when exploring the impact of vascular traits on late-onset diseases like dementia.
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Study finds causal evidence tying cerebral small-vessel disease to Alzheimer's and dementiaResearch led in part by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) finds that the most common cerebral small-vessel disease feature seen in brain magnetic resonance imaging is a primary vascular factor associated with dementia risk.
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