Study reveals exercise and GLP-1 RA combination preserves bone health during weight loss

By Vijay Kumar MalesuReviewed by Susha Cheriyedath, M.Sc.Jun 27 2024 In a recent study published in the JAMA Network Open, a group of researchers evaluated the impact of exercise, glucagon-like peptide-1 receptor agonist liraglutide, and their combination on bone health at the hip, spine, and forearm following diet-induced weight loss in adults with obesity.

About the study The present study was conducted from August 2016 to November 2019 at Hvidovre Hospital and the University of Copenhagen. It was approved by the Regional Ethics Committee in Denmark and the Danish Medicines Agency, following Consolidated Standards of Reporting Trials guidelines. Participants aged 18-65 with a body mass index of 32-43 provided informed consent. Those with serious chronic illnesses, including diabetes, were excluded.

Study results A total of 195 participants completed the low-calorie diet and were randomized into four groups: exercise , liraglutide , combination , and placebo . BMD measurements were available for 158 to 161 participants at week 52. No participants were on osteoporosis medications, and no fragility fractures occurred. Safety outcomes were reported previously.

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