Combining donepezil and memantine extends lives of Alzheimer's patients, study finds

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Donepezil News

Alzheimer's Disease,Drugs,Efficacy

Alzheimer's disease is the world's most common neurodegenerative disease, affecting more than 50 million people globally.

Jun 12 2024Chapman University Alzheimer's disease is the world's most common neurodegenerative disease, affecting more than 50 million people globally. Alzheimer's disease is also among the most fatal, landing as one of the top five causes of death worldwide. However, most currently available treatments are limited to alleviating the disease's symptoms.

The study, "Combine use of Donepezil and Memantine increases the probability of five-year survival of Alzheimer's disease patients", was released this month in Communications Medicine, finds that combining the use of the two most common Alzheimer's disease drugs, Donepezil and Memantine, could extend the lives of approximately 303,000 people with Alzheimer's Disease living in the USA beyond five years from diagnosis.

Then, the authors implemented advanced statistical techniques to achieve unbiased estimates of treatment effects and ensure the robustness of results. With these analyses in place, they confirmed a significant, beneficial drug-drug interaction, indicating that the combined use of Donepezil and Memantine significantly increased the probability of five-year survival of Alzheimer's disease patients compared to no drug use and single drug use of Memantine and Donepezil.

 

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