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'It's given me longer': New drugs give hope of slowing down one of the most feared diseases

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Clinical trials of two new Alzheimer's drugs have shown promising results. While questions remain about their side effects, many scientists believe they represent a turning point: for the first time, they have been able to slow down the disease.

Retired furniture maker David started developing Alzheimer's disease around eight years ago. "I was working away, and all of a sudden, I suddenly couldn't remember what I was supposed to do next," he said. "I thought, 'This is really weird', and I just forgot." David is one of around 600,000 people in the United Kingdom with Alzheimer's, the most common form of dementia.

Lecanemab and Donanemab are antibodies like those made by our body to attack viruses or bacteria and have been engineered to bind to amyloid and help immune cells clear it away. But there can be fatal consequences, as the drugs can cause swelling or bleeding in the brain. MacSweeney said this is a side effect called ARIA, which stands for amyloid-related imaging abnormalities. " ballpark 35 per cent of people taking this class of medication will develop ARIA, but only about 3.

 

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