Researchers have discovered that a father’s diet before conception significantly impacts the health of his children. The artwork features an allegorical representation of a fertilization event whereby a fat spermatozoon , conquers the oocyte and lights it up by transferring diet-induced epigenetic information. Credit: Philipp Beck
Dr. Raffaele Teperino, who leads the “Environmental Epigenetics” research group at Helmholtz Munich, and his team have explored how a father’s diet prior to conception affects the health of their children. The study concentrated on specific smallmolecules present in sperm, termed mitochondrial tRNA fragments . These RNAs are crucial in transmitting health traits across generations by controlling gene expression.
To deepen the findings, the research team conducted additional studies in the laboratory. They created embryos through in-vitro fertilization . When Teperino’s team used sperm from mice that had been exposed to a high-fat diet, they found mt-tsRNAs from these sperm in early embryos, significantly influencing gene expression. This, in turn, affects the development and health of the offspring.
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