By Dr. Priyom Bose, Ph.D.Jun 2 2024Reviewed by Benedette Cuffari, M.Sc. A recent Nutrients journal study reviewed the efficacy of omega-3 polyunsaturated fatty acids in modulating the progression of osteoarthritis .
At joint surfaces, articular cartilage facilitates a low friction area and greater load transmission with joint articulations. In addition to articular cartilage, OA can also adversely impact the ligaments, adjacent synovium, and subchondral bone, all of which contribute to joint pain. Omega-3 supplementation and reduced inflammation in OA Omega-3 PUFAs are associated with anti-inflammatory effects that have been shown to reduce carcinogen and vascular biomarkers, including those associated with chronic inflammation, metabolic diseases, and conditions that reduce the strength of the musculoskeletal system.
Individuals with greater intakes of saturated fatty acids have also been shown to exhibit reduced joint space width. However, this effect was not observed among those consuming more PUFAs. Omega-3 PUFAs, OA, and comorbidities Cardiovascular morbidity is inversely related to aerobic exercise, which is often negatively affected due to OA. Previous studies have shown that individuals supplementing with eicosapentaenoic acid and DHA exhibit significant reductions in triglyceride levels, neutrophil counts, and white blood cell counts, thus implying that omega-3 supplementation has the potential to mitigate adverse musculoskeletal events and preserved physical function.
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