Personalized dietary programs outperform general advice for better heart health

By Dr. Priyom Bose, Ph.D.May 13 2024Reviewed by Benedette Cuffari, M.Sc. In a recent Nature Medicine study, researchers compare the effectiveness of personalized dietary programs and general advice on cardiometabolic health.

In fact, one recent study revealed that less than 1% of the United Kingdom population adheres to all dietary recommendations, with similarly poor adherence reported in the United States. Multiple factors influence the variability in health responses to food; therefore, effective personalized nutrition programs based on lifestyle and phenotypic biological factors could increase compliance rates with dietary guidelines.

Standard care dietary advice was obtained from the United States Dietary Guidelines for Americans 2020-2025, whereas PDP dietary guidelines were based on the ZOE 2022 algorithm. PDP recommendations were based on an individual’s health history, gut microbiome composition, and glucose and postprandial triglycerides levels. The dietary and lifestyle recommendations for PDP were delivered remotely through a phone application called ZOE.

Related StoriesA greater variation in nutritional intake and individual food was associated with PDP compared to the control group. An improved and sustained gut microbial composition was observed in the PDP group compared to the control, with these microbiome changes more predictive of weight loss and reduction in hip circumference than the control diet.

Consistent with previous studies, the current study observed that TG levels were sensitive to nutritional interventions. Significantly, LDL-C levels do not change with weight loss induced by dietary modification.

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