May 7 2024Ludwig Institute for Cancer Research
Cellular immunotherapy involves extracting immune cells from a patient's tumor, optionally engineering them to enhance their natural abilities to combat cancer and reintroducing them to the body after they've been expanded in culture. T cells are one of the two main types of white blood cells, or lymphocytes, that circulate in the blood and patrol for virally infected or cancerous cells.
TRTpred can learn from one T cell population and create a rule which can then be applied to a new population. So, when faced with a new TCR, the model can read its transcriptomic profile and predict whether it is tumor reactive or not." Related StoriesThe TRTpred model analyzed TILs from 42 patients with melanoma and gastrointestinal, lung and breast cancer and identified tumor-reactive TCRs with about 90 percent accuracy.
The team then introduced a third filter to maximize recognition of diverse tumor antigens. "What we want is to maximize the chances the TILs will target as many different antigens as possible," Harari said.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
Health Health Latest News, Health Health Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Research team develops novel PTPN2/N1 inhibitor for cancer immunotherapy using generative AIIn recent years, cancer immunotherapy, exemplified by PD-1 and its ligand PD-L1 blockade, has made remarkable advances. But while immunotherapy drugs offer new treatment possibilities, only about 20% to 40% of patients respond to these treatments. The majority either don't respond or develop drug resistance.
Source: medical_xpress - 🏆 101. / 51 Read more »
AI predicts tumor-killing cells with high accuracy, study showsUsing artificial intelligence, Ludwig Cancer Research scientists have developed a powerful predictive model for identifying the most potent cancer-killing immune cells for use in cancer immunotherapies.
Source: medical_xpress - 🏆 101. / 51 Read more »
Breast Cancer Now funds new research to investigate how breast cancer cells survive and growResearchers in Sheffield are investigating how breast cancer cells survive and grow, thanks to new funding from Breast Cancer Now.
Source: NewsMedical - 🏆 19. / 71 Read more »
Belfast mum diagnosed with cancer after noticing 'odd-looking spot'Lyn's skin cancer was detected by the Action Cancer's skin cancer detection service
Source: BelfastLive - 🏆 16. / 77 Read more »
Research shows altered regulation of genes linked to prostate cancer among firefightersFirefighters may have an increased risk of prostate cancer due to on-the-job chemical exposures, according to new research from the University of Arizona Mel and Enid Zuckerman College of Public Health and University of Michigan in collaboration with fire service partners and researchers around the country through the Fire Fighter Cancer Cohort...
Source: medical_xpress - 🏆 101. / 51 Read more »