Chemotherapy linked to physical decline in older women with high-risk breast cancer

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Breast Cancer News

Cancer,Chemotherapy,Aging

A UCLA-led study suggests women who are 65 years old or older with high-risk breast cancer and are treated with chemotherapy are more likely to develop a substantial decline in physical function.

May 10 2024University of California - Los Angeles Health Sciences

We have previously shown that chemotherapy can contribute to a decline in physical function in breast cancer survivors, but it wasn't fully understood if the decline was primarily driven by the cancer, chemotherapy or both. It's important to have this comparison to determine whether or not this decline represents an acceleration of the aging process itself."

To better understand the impact of breast cancer treatment on aging-related decline in physical function, the team performed a multicenter prospective study that compared the changes in physical function over time in women over the age of 65. Participants included 444 women with early-stage breast cancer receiving chemotherapy, 98 women with early-stage breast cancer not receiving chemotherapy, and 100 women without cancer of the same age.

Related StoriesAmong the participants who experienced a substantial decline, the activity most adversely affected was climbing several stairs , followed by walking one mile and engaging in moderate activity .

 

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