The Staff Scientist will be the primary scientist to evaluate mitochondria pathways associated with treatment resistance in esophageal cancer. This project will focus on the epigenetic and mitochondrial mechanisms that prevent response to immunotherapy or chemotherapy directly in human tumor samples as well as mice and cell culture. The project will require in vivo assessment in mouse models including already developed patient-derived xenografts and patient-derived explants .
Design, plan and execute tumor metabolism experiments including Seahorse XF assays and mitochondrial imagingDesign, plan and perform basic molecular biology and cell culture techniquesDesign, plan and perform experiments using mutation detection, gene expression profiling, chromatin immunoprecipitation, DNA/RNA-protein interactions cell culture, lentiviral transductions, and transcriptomic analysisDesign, plan and execute in vivo experiments using mouse modelsMentor students and postdocs in the...
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