Combination immunotherapy treatment enhances immune response for people with malignant gliomas

May 9 2024University of California - Los Angeles Health Sciences Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.

Robert Prins, professor of molecular and medical pharmacology and of neurosurgery at the David Geffen School of Medicine at UCLA, and co-senior author of the study While the vaccine has shown promise in treating patients with malignant gliomas, the treatment does not work for everyone. The team enrolled 23 patients, ranging from 26- to 72-years-old, with WHO Grade III-IV glioma who were randomized to receive either poly-ICLC, resiquimod or a placebo in addition to the personalized DC vaccine.

Most notably, the expression of PD-1 surged in CD4+ T-cells, while CD38 and CD39 levels diminished in CD8+ T-cells. There was a notable rise in the number of monocytes, which are key players in the immune response. Patients who show no or low interferon response after the therapy could be directed towards other treatments or clinical trials more quickly, saving valuable time in their fight against this aggressive form of brain cancer.

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