How the Crimean-Congo hemorrhagic fever virus enters our cells

Researchers at Karolinska Institutet, in collaboration with JLP Health and others, have identified how the tick-borne Crimean-Congo haemorrhagic fever virus enters our cells. The results are published inand are an important step in the development of drugs against the deadly disease.

To identify the protein, the researchers used human mini-organs grown in test tubes and an advanced stem cell library from JLP Health. The same platform has previously been used to identify how the Ebola virus enters cells. This knowledge is essential if the disease were to become more common and spread to new areas. Normally it takes many years to develop a drug, but the COVID-19 pandemic and the development of the SARS-CoV-2 vaccine showed that it can be done much faster if everyone decides it is a priority."This is an important step in our preparedness for the disease," says Ali Mirazimi."Crimean-Congo haemorrhagic fever is a disease we would rather not have.

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