Metabolic syndrome increases mortality risk in women with high-risk HPV

Mar 9 2024York University Using large-scale U.S. data following patients for more than a decade, York University Faculty of Health researchers found that women with both metabolic syndrome and high-risk strains of human papillomavirus are at a 2.6 times higher risk for mortality than women without either condition, suggesting a need to look at chronic disease comorbidity when it comes to HPV-related cancers.

Data for the study, published yesterday in PLOS ONE, was obtained by the United States National Health and Nutrition Examination Survey with a final sample of 5,101 individuals . The researchers found more than a quarter of the women with metabolic syndrome had high-risk HPV. Catriona Buick, Assistant Professor and Oncology Nurse Clinician Scientist, Sunnybrook Health Sciences Centre

Related Stories"It likely has something to do with a weakened immune response and chronic inflammation, but the research looking at a direct physiological pathway still needs to be done," said Mirzadeh.

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