Study supports use of reduced-dose of direct oral anticoagulants for many older adults with two or more conditions

Association of standard‐ vs reduced‐dose direct oral anticoagulants on outcomes. Detailed event rates, individuals at risk, and follow‐up times are presented in Table S6. IPTW indicates inverse probability treatment‐ and inverse probability censor‐weighted. Credit:DOACs can prevent serious thrombotic events like stroke in residents with nonvalvular atrial fibrillation and have a lower risk of major bleeding events than warfarin.

Persons receiving standard-dosing of DOACs experienced 1.4 more major bleeds per 100 person-years than those on reduce-dosing, with highest relative bleeding rates among those aged ≥80 years or who were not obese. Over the 1-year follow-up period, the overall rate of major bleeds in this population was 8.6 per 100 person-years and 5.7 per 100 PY for thrombotic events.in the article, Benefits and Harms of Standard versus Reduced-Dose Direct Oral Anticoagulant Therapy for Multimorbid Older Adults with Atrial Fibrillation, published in theKaleen N.

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