By Hugo Francisco de SouzaNov 7 2023Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal eBioMedicine, researchers used proteomics to investigate differentially expressed proteins associated with long-COVID. Identified up- or down-regulated proteins were characterized via ingenuity pathway analyses to elucidate their downstream pathological and physiological effects.
Long-COVID has had severe and widespread impacts on COVID-19 survivors’ quality of life. The condition has further resulted in national-scale economic loss, as seen in the United Kingdom and Europe, wherein its prevalence has been directly responsible for early retirement and shortages in the employment market. This is mainly due to the physical and neurological debilitation brought about by long-COVID, which may persist for two years or more.
About the study In the present study, researchers investigated the proteomic landscape surrounding long-COVID to identify protein biomarkers that may serve as future diagnostic determinants of the condition and provide insights into the pathophysiological impacts of severe SARS-CoV-2 infections on survivors.
To elucidate the pathophysiological changes in COVID-19 survivors, 181 age- and sex-matched health controls were recruited from Wuhan, China, and underwent the same battery of tests as the case-cohort . Additionally, demographic, clinical, disease severity , and medical intervention data was collected from hospital records or self-reported for controls.
Study findings Demographic and clinical data revealed significant long-term symptoms in COVID-19 cases, including physical and clinical . Proteomics analysis in combination with PCAs revealed distinct stratification of COVID-19 survivors into three cohorts, corroborated between all three follow-up visits.
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