Reviewed by Danielle Ellis, B.Sc.Oct 26 2023 At the heart of the proposed method are enzyme-mimicking molecular catalysts capable of producing various types of anti-cancer drugs within the tumor tissue itself. According to Joost Reek, professor of Supramolecular Catalysis at the University of Amsterdam and coordinator of the 'Cat4CanCenter' research, this new approach could potentially solve many of the difficulties associated with the current treatment of glioblastoma.
The advantage of this approach is that the tumor can be 'loaded' with high levels of drugs without the adverse effects normally associated with drug treatments. Current therapies involve administering high doses in the bloodstream to ensure that enough drugs can cross the blood-brain barrier and arrive at the brain tumour site.
Effective metal catalysis Prof. Reek will use his expertise to design the caged catalysts that will perform the synthesis of the desired drug molecules. He explains that in recent years his team has developed caged catalysts that allow metal-catalyzed synthesis in a biological environment. Concurrent remedies Indeed, the Cat4CanCenter will investigate multiple drugs that together target the combined crucial aspects of the aggressive behaviour of glioblastomas. The effectiveness of these strategies will be studied in detail in near-patients model systems and pre-clinical studies at the Netherlands Cancer Institute directed by Dr Akkari. Her expertise lies in particular in the glioblastoma immune response and the tumor-assisted macrophage biology.
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