Researchers discover new way to trigger programmed cell death in cancer cells

Reviewed by Megan Craig, M.Sc.Oct 24 2023 This new ability to trigger programmed cell death could open the door for improved cancer treatments. The findings were published Oct. 14 in the Nature journal Cell Death & Differentiation.

We have found the most critical epitope for cytotoxic Fas signaling, as well as CAR T-cell bystander anti-tumor function." Finding better cancer therapies Cancer is generally managed with surgery, chemotherapy and radiotherapy. These treatments may work initially, but in some cases, therapy-resistant cancers often return. Immunotherapies, such as CAR T-cell-based immune therapies and immune checkpoint receptor molecule activating antibodies, have shown tremendous promise to break this cycle.

Death receptors do precisely what their name implies -; when targeted, they trigger programmed cell death of tumor cells. They offer a potential workaround that could simultaneously kill tumor cells and pave the way for more effective immunotherapies and CAR T-cell therapy. Other research in animal models and human clinical trials has shown that Fas signaling is fundamental to CAR T success, particularly in tumors that are genetically heterogeneous. Genetically heterogeneous tumors have a mix of different cell types, which can respond differently to treatment.

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