Childhood cancer survivors at high risk for skin malignancies

- As adults, childhood cancer survivors have a 30-fold higher risk than the general population of developing common skin malignancies known as basal cell carcinoma, a Dutch study suggests.

"This property of ionizing radiation is essential in killing the cancer cells, but can also cause DNA damage to surrounding tissues that inevitably also receive some level of radiation exposure during radiotherapy, for example the skin," Teepen said by email."DNA damage can increase the chance of developing cancer later in life."

During the study, 259 childhood cancer survivors developed a total of 1,061 cases of basal cell carcinoma, there were 27 melanomas among 20 survivors and 11 squamous cell carcinomas among 10 survivors. The study wasn't designed to prove whether or how childhood tumors or treatments used to attack these malignancies might directly cause skin cancer later in life.

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