By Pooja Toshniwal PahariaOct 4 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature's Experimental & Molecular Medicine, researchers developed the ATRIVIEW® platform to screen for molecules that promote differentiation of adult murine neural stem cells .
Despite discovering Alzheimer's disease medicines to remove these tau tangles and plaques, disease-modifying drugs have proven ineffective. Improving adult neurogenesis in the brain might be a possible Alzheimer's disease treatment method. In addition, Western blot analysis, quantitative reverse transcription-polymerase chain reaction , and whole-cell ribonucleic acid sequencing were performed. Gene expression was assessed by performing differential gene expression analysis and gene ontology analysis.
To determine whether the mitogen-activated protein kinase /extracellular signal-related kinase pathway was activated in NSCs of AD model mice with amyloid beta plaque phenotypes, the team measured the phosphorylated ERK level in the brains of WT and 5XFAD AD model mice. In vitro, trametinib elevated levels of the P15INK4b and the proneuronal factor neurogenin 2 , revealing a mechanism by which MEK1/2 inhibition drives neuronal differentiation.
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