By Pooja Toshniwal PahariaOct 3 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Cell, researchers examined 152,459 microglial transcriptomes from 443 individuals, identifying 12 transcriptional states and their relationship to Alzheimer's disease .
The researchers tested the potential of transcription factors to control microglial states in AD using microglia-like cells derived from stem cells.
Through immunohistochemistry and RNAscope in situ hybridization, the researchers experimentally verified the enrichment of important states of transcription in the AD human brain. They also used enrichment analysis to determine the expression of disease-associated microglia genes throughout the dataset.
Results The researchers examined 12 microglia transcription states, including lipid-processing, homeostatic, and inflammatory states associated with Alzheimer's disease., including Alzheimer's disease-related lipid-processing, homeostatic, and inflammatory states. There were 1,542 Alzheimer's disease-differentially expressed genes discovered, including illness-stage-specific and microglia-state-specific changes.
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