The nasal spray from Johnson & Johnson is a chemical cousin of ketamine, which has been used for decades as a powerful anesthetic to prepare patients for surgery. In the 1990s, the medication was adopted as a party drug by the underground rave culture due to its ability to produce psychedelic, out-of-body experiences. More recently, some doctors have given ketamine to people with depression without formal FDA approval.
Ketamine and J&J's version work differently than those drugs, targeting a chemical called glutamate that is thought to restore brain connections that help relieve depression. Robin Prothro, 60, began taking antidepressants more than 20 years ago. But she says none of the five medications she tried relieved the depression that has stymied her personal and professional life.
"Substantially different agents are only rarely appearing from pharmaceutical companies or other laboratories," said Dr. Paul Summergrad, a psychiatrist at Tufts University."That's prompting people to investigate other compounds."
Known among Scientific Shamans
This still makes sense. It's not like he's aware of that, but the fact that doctors are trying to stop him from treating his depression.
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