These models have made it possible to identify key factors in the onset and maintenance of arrhythmias. It has thus been demonstrated that cardiac mathematics is able to support and consolidate the electrophysiological study in the localization of intervention areas on the heart wall.
In collaboration with Ospedale Sacco di Milano, a model was also developed to guide cardiac surgeons in removing part of the interventricular septum to treat hypertrophic obstructive cardiomyopathy. Mathematical simulation is part of the pre-operative phase, and has been considered by doctors as an effective guidance tool for this delicate surgery.
In collaboration with Ospedale Santa Maria del Carmine in Rovereto , a mathematical tool was created to optimize cardiac resynchronization therapy. This reduces the time for mapping the, which is necessary for implanting a resynchronization device, and thus also reduces the patient's exposure time in invasive treatments, and guides the placement of the catheter in the most curative location for the decompensated patient.
iHEART Simulator is the result of years of research within the"iHEART" project. The project, directed and coordinated by Professor Alfio Quarteroni, ran from 2017 to 2023, and aimed to develop the first comprehensive mathematical model of the human heart and its diseases., where he was awarded the Lagrange Prize by the International Council for Industrial and Applied Mathematics .