What is the tick-borne disease alpha-gal and why does it cause an allergy to meat?

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As more cases of the rare tick-borne disease alpha-gal are reported in the UK, what is it, and why does it cause an allergic reaction to meat in some cases?

'Risk of biting common all year round'

"In previous years we didn't see them bite in the winter, it'd be a spring peak of tick biting, then there'd be no biting in the summer, and then a smaller peak in the autumn, but now with the changing climate we're seeing them certainly biting all winter and we're seeing a gradual change in seasonal patterns. So, the risk of biting is now fairly common all season round.

They can include stomach cramps, diarrhoea, hives and shortness of breath that could trigger fatal anaphylaxis, a potentially life-threatening reaction involving multiple organ systems, which may need urgent medical care.

 

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Smoking behavior change and risk of cardiovascular disease incidence and mortality in patients with type 2 diabetes mellitus - Cardiovascular DiabetologyBackground We aimed to examine the association between smoking behavior change and risk of cardiovascular disease (CVD) incidence and mortality in patients with type 2 diabetes mellitus (T2DM). Methods This study used nationwide data from the Korean National Health Insurance System and included 349,137 T2DM patients who smoked. Smoking behavior changes were defined with five groups: quitters, reducers I (≥ 50% reduction), reducers II (20–50% reduction), sustainers (± 20%), and increasers (≥ 20% increase) from the number of cigarettes/day at the baseline. Results During a median follow-up of 5.1 years, 6,514 cases of myocardial infarction (MI) (1.9%), 7,837 cases of ischemic stroke (IS) (2.2%), and 14,932 deaths (4.3%) were identified. Quitters had a significantly decreased risk of MI (adjusted hazard ratio [aHR] 0.80, 95% CI 0.75–0.86) and IS (aHR 0.80, 95% CI 0.75–0.85) compared to sustainers, whereas reducers did not have a significant association with the risk of MI (aHR 1.03, 95% CI 0.94–1.13) and IS (aHR 1.00, 95% CI 0.92–1.08) in reducer I. Quitters also had a lower all-cause and CVD mortality than sustainers. Conclusions Smoking cessation was associated with decreased CVD incidence, and all-cause and CVD mortality among T2DM patients. However, smoking reduction was not associated with decreased risks for these.
Source: BioMedCentral - 🏆 22. / 71 Read more »